The transportation system is often disrupted by natural hazards and human-made accidents, which cause severe consequences to people’s mobility, the local economy, and the society in general. Particularly, the more and more frequent and severe impacts of climate change are posing great challenges and will continue to impact the globe for many years. Building resilient multimodal interconnected transportation systems under such attacks are critical for the safe and efficient movement of people and goods. However,...

The End-to-End (E2E) architecture has emerged in recent years as a novel and promising paradigm for autonomous driving. The robustness and safety issue in complex real-world environments pose significant challenge to the development of E2E autonomous driving system. The quantitative measure of confidence of intermediate features in E2E perception and prediction is missing, and the propagation of uncertainties among the modules of E2E framework requires explicit analysis. In addition, learning-based control techniques (e,g, Reinforcement Learning)...

This research seminar introduces human cognitive modeling with its applications in intelligent transportation systems (ITS) design. Human cognitive modeling is a growing and challenging area in human factors and cognitive systems engineering. It builds computational models based on the fundamental mechanisms of human cognition and human-system interaction, employs both mathematical and discrete event simulation methods in industrial engineering, and predicts human performance and workload in real-world transportation systems. It can be used to design, improve,...

The Hippo pathway has emerged as an evolutionarily conserved signaling network that regulates cell proliferation, tissue homeostasis, and tissue regeneration. We show that the tumor suppressor Merlin, an upstream regulator of the Hippo pathway, forms solid-like condensates that activate Hippo signaling in Drosophila tissues. Merlin condensation required phosphatidylinositol-4-phosphate (PI4P)-mediated plasma membrane targeting, and was antagonistically controlled by Pez and cytoskeletal tension through plasma membrane PI4P regulation. The solid-like material properties of Merlin condensates are essential...